Two months ago we posted a blog (http://blog.standupandeat.org/post/2009/08/Can-You-Outwit-Your-Genes.aspx) that described recent research suggesting that physical activity may reduce the high body mass index (obesity) level that might otherwise be expected in people with a specific gene variant, the FTO gene.

New research shows that diet, too, may play a bigger role than genes in obesity. Published in the September 2009 issue of the American Journal of Clinical Nutrition¹, researchers analyzed eating habits of almost 5,000 people with and without the FTO gene variant. The risk of becoming obese was found to be 2.5 times higher for those who have double copies of the FTO gene variant, but only if their fat consumption was high. A low fat diet was shown to "neutralize" the harmful effects of the gene.

Thus, a low-fat diet is important for everyone, including those with an inherited predisposition to obesity. While family history may continue to increase risk for overweight and obesity, healthy lifestyle choices can override this risk.

So no more excuses everyone - replace fried foods with fresh, whole foods and sedentary activities with movement!   

¹ Sonestedt, Emily, Roos, Charlotta, Gullberg, Bo, Ericson, Ulrika, Wirfalt, Elisabet, Orho-Melander, Marju. Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity. American Journal of Clinical Nutrition, 2009.